NF-κB
Nuclear factor kappa B — a transcription factor central to inflammatory gene expression.
For laboratory and research use only — not for human consumption.
NF-κB is a family of inducible transcription factors (RelA/p65, p50, c-Rel, RelB, p52) that drive expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), chemokines, adhesion molecules, and anti-apoptotic genes. Constitutive activation is a feature of inflammatory bowel disease, rheumatoid arthritis, and many chronic wounds. KPV's principal mechanism is direct intracellular interaction with NF-κB pathway components; LL-37 modulates the pathway through FPR2 signalling. Suppression of NF-κB-driven cytokine release is a common downstream endpoint in anti-inflammatory peptide research.